The involvement of the central nervous system (CNS) by schistosomes may or may not
determine clinical manifestations. When symptomatic, neuroschistosomiasis (NS) is one of
the most severe presentations of schistosome infection. Considering the symptomatic form,
Schistosoma mansoni causes almost always spinal cord disease. Cerebral and spinal cord
disorders in S. mansoni infections are inflammatory conditions of the CNS that cause mild–
moderate impairment of the blood–brain barrier and intrathecal synthesis of antibodies …