CD4+ CD25+ regulatory T cells do not significantly contribute to direct pathway hyporesponsiveness in stable renal transplant patients
DS Game, MP Hernandez-Fuentes… - Journal of the …, 2003 - journals.lww.com
CD4+ CD25+ regulatory T cells have been shown to regulate a variety of autoimmune and
allogeneic responses in mice and humans. The role of CD4+ CD25+ cells in regulating
alloresponses in human transplant recipients remains uncertain. Previous research has
demonstrated a reduced frequency of direct pathway donor-specific T cells in renal
transplant recipients when compared with the frequency of T cells reactive to an HLA-
matched third party. A number of mechanisms have been proposed to account for this …
allogeneic responses in mice and humans. The role of CD4+ CD25+ cells in regulating
alloresponses in human transplant recipients remains uncertain. Previous research has
demonstrated a reduced frequency of direct pathway donor-specific T cells in renal
transplant recipients when compared with the frequency of T cells reactive to an HLA-
matched third party. A number of mechanisms have been proposed to account for this …