Flotillin-1/reggie-2 traffics to surface raft domains via a novel Golgi-independent pathway: identification of a novel membrane targeting domain and a role for …
Flotillins are lipid raft-associated proteins, which have been implicated in neuronal
regeneration and insulin signaling. We now show that newly synthesized flotillin-1 reaches
the plasma membrane via a Sar1-independent and brefeldin A-resistant targeting pathway.
Consistent with post-translational membrane association of flotillin, protease sensitivity
experiments suggest that flotillin-1 is not a transmembrane protein but is associated with the
cytoplasmic face of the plasma membrane. The N terminus of flotillin contains a prohibitin …
regeneration and insulin signaling. We now show that newly synthesized flotillin-1 reaches
the plasma membrane via a Sar1-independent and brefeldin A-resistant targeting pathway.
Consistent with post-translational membrane association of flotillin, protease sensitivity
experiments suggest that flotillin-1 is not a transmembrane protein but is associated with the
cytoplasmic face of the plasma membrane. The N terminus of flotillin contains a prohibitin …
