The salivary glands as a privileged site of cytomegalovirus immune evasion and persistence
AE Campbell, VJ Cavanaugh, JS Slater - Medical microbiology and …, 2008 - Springer
AE Campbell, VJ Cavanaugh, JS Slater
Medical microbiology and immunology, 2008•SpringerThe salivary glands (SG) provide a haven for persistent cytomegalovirus replication, and in
this regard are a privileged site of virus immune evasion. The murine cytomegalovirus
(MCMV) model has provided insight into the immunological environment of the SG and the
unqiue virus–host relationship of this organ. In response to MCMV infection, a robust T cell-
mediated immune response is elicited, comprised predominantly of CD8+ T cells that
phenotypically and functionally appear activated. However, they fail to clear virus by an …
this regard are a privileged site of virus immune evasion. The murine cytomegalovirus
(MCMV) model has provided insight into the immunological environment of the SG and the
unqiue virus–host relationship of this organ. In response to MCMV infection, a robust T cell-
mediated immune response is elicited, comprised predominantly of CD8+ T cells that
phenotypically and functionally appear activated. However, they fail to clear virus by an …
Abstract
The salivary glands (SG) provide a haven for persistent cytomegalovirus replication, and in this regard are a privileged site of virus immune evasion. The murine cytomegalovirus (MCMV) model has provided insight into the immunological environment of the SG and the unqiue virus–host relationship of this organ. In response to MCMV infection, a robust T cell-mediated immune response is elicited, comprised predominantly of CD8+ T cells that phenotypically and functionally appear activated. However, they fail to clear virus by an unknown evasion mechanism that is independent of inhibitory NKG2A- or Programmed Death 1-mediated signaling. Virus is eventually eliminated from the SG by effector CD4+ T cells expressing antiviral cytokines. However, this mechanism is severely dampened by high levels of the immunosuppressive cytokine IL-10, selectively expressed by SG CD4+ T cells.
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