Lung fibrosis and emphysema: divergent responses to a common injury?
DE Niewoehner, JR Hoidal - Science, 1982 - science.org
DE Niewoehner, JR Hoidal
Science, 1982•science.orgCadmium chloride, administered intratracheally to golden Syrian hamsters, causes an acute
lung injury which evolves into a lesion with functional and morphological features of diffuse
fibrosis. With simultaneous feeding of a lathyrogen, β-aminoproprionitrile, this same injury
evolves into functional and morphological changes of bullous emphysema. These results
suggest that the same lung injury might result in either fibrosis or emphysema, connective
tissue synthesis during the healing phase being the critical determinant.
lung injury which evolves into a lesion with functional and morphological features of diffuse
fibrosis. With simultaneous feeding of a lathyrogen, β-aminoproprionitrile, this same injury
evolves into functional and morphological changes of bullous emphysema. These results
suggest that the same lung injury might result in either fibrosis or emphysema, connective
tissue synthesis during the healing phase being the critical determinant.
Cadmium chloride, administered intratracheally to golden Syrian hamsters, causes an acute lung injury which evolves into a lesion with functional and morphological features of diffuse fibrosis. With simultaneous feeding of a lathyrogen, β-aminoproprionitrile, this same injury evolves into functional and morphological changes of bullous emphysema. These results suggest that the same lung injury might result in either fibrosis or emphysema, connective tissue synthesis during the healing phase being the critical determinant.
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