The distinct proteome of placental malaria parasites
M Fried, KK Hixson, L Anderson, Y Ogata… - Molecular and …, 2007 - Elsevier
Malaria proteins expressed on the surface of Plasmodium falciparum infected erythrocytes
(IE) mediate adhesion and are targeted by protective immune responses. During pregnancy,
IE sequester in the placenta. Placental IE bind to the molecule chondroitin sulfate A (CSA)
and preferentially transcribe the gene that encodes VAR2CSA, a member of the PfEMP1
variant surface antigen family. Over successive pregnancies women develop specific
immunity to CSA-binding IE and antibodies to VAR2CSA. We used tandem mass …
(IE) mediate adhesion and are targeted by protective immune responses. During pregnancy,
IE sequester in the placenta. Placental IE bind to the molecule chondroitin sulfate A (CSA)
and preferentially transcribe the gene that encodes VAR2CSA, a member of the PfEMP1
variant surface antigen family. Over successive pregnancies women develop specific
immunity to CSA-binding IE and antibodies to VAR2CSA. We used tandem mass …