NFκB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis

F Kühnel, L Zender, Y Paul, MK Tietze… - Journal of Biological …, 2000 - ASBMB
NFκB is an essential survival factor in several physiological conditions such as embryonal
liver development and liver regeneration. However, NFκB is also a main mediator of the
cellular response to a variety of extracellular stress stimuli, and it has been shown that some
viral-induced host cell apoptosis appears to be dependent on NFκB activation. The
activation of NFκB upon viral infection may be a rapid way of initiating an innate immune
response against the viral particles. We have assessed the role of NFkB during the early …