Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions
K Arias, M Baig, M Colangelo, D Chu, T Walker… - Journal of allergy and …, 2009 - Elsevier
BACKGROUND: Food anaphylaxis is an acute and life-threatening systemic allergic
reaction. Fatality registries place peanut as the most common culprit of fatal and near-fatal
reactions in North America. Because prophylaxis and treatment have advanced little in
recent years, it is imperative to evaluate novel therapies. OBJECTIVE: To investigate the
impact of blocking mast cell mediators in a mouse model of peanut-induced anaphylaxis.
METHODS: Mice were sensitized with peanut protein and cholera toxin via oral gavage …
reaction. Fatality registries place peanut as the most common culprit of fatal and near-fatal
reactions in North America. Because prophylaxis and treatment have advanced little in
recent years, it is imperative to evaluate novel therapies. OBJECTIVE: To investigate the
impact of blocking mast cell mediators in a mouse model of peanut-induced anaphylaxis.
METHODS: Mice were sensitized with peanut protein and cholera toxin via oral gavage …