Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

H Bernheimer, W Birkmayer, O Hornykiewicz… - Journal of the …, 1973 - Elsevier
A clinical, morphological and neurochemical correlative study in patients with Parkinson's
syndrome and Huntington's chorea is reported. In the former group of patients, 69 brains
were examined morphologically and 28 biochemically; in the latter group, 4 brains were
examined morphologically and 14 biochemically. The results were as follows:(1) The main
morphological alteration common to all forms of Parkinsonism was damage to the substantia
nigra with a loss of the melanin-containing nerve cells in the zona compacta; the degree and …