Obliterative bronchiolitis (OB) or chronic graft dysfunction remains the major limitation to
long-term success of lung transplantation. Investigation using animal models is a critical
component of research to understand the underlying pathological mechanisms and to
develop novel preventive and therapeutic strategies for OB. Multiple animal models of OB
exist, including orthotopic lung transplantation in rodents and large animals, orthotopic
tracheal transplantation and heterotopic transplantation of a trachea in variable sites such as …