JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies
W Vainchenker, A Dusa, SN Constantinescu - Seminars in cell & …, 2008 - Elsevier
W Vainchenker, A Dusa, SN Constantinescu
Seminars in cell & developmental biology, 2008•ElsevierThe four mammalian Janus kinase (JAK) family members, JAK1, JAK2, JAK3 and TYK2, are
non-receptor protein tyrosine kinases (PTKs) that are crucial for cytokine receptor signaling
in blood formation and immune responses. Mutations and translocations in the JAK genes
leading to constitutively active JAK proteins are associated with a variety of hematopoietic
malignancies, including the myeloproliferative disorders (JAK2), acute lymphoblastic
leukemia (JAK2), acute myeloid leukemia (JAK2, JAK1), acute megakaryoblastic leukemia …
non-receptor protein tyrosine kinases (PTKs) that are crucial for cytokine receptor signaling
in blood formation and immune responses. Mutations and translocations in the JAK genes
leading to constitutively active JAK proteins are associated with a variety of hematopoietic
malignancies, including the myeloproliferative disorders (JAK2), acute lymphoblastic
leukemia (JAK2), acute myeloid leukemia (JAK2, JAK1), acute megakaryoblastic leukemia …
The four mammalian Janus kinase (JAK) family members, JAK1, JAK2, JAK3 and TYK2, are non-receptor protein tyrosine kinases (PTKs) that are crucial for cytokine receptor signaling in blood formation and immune responses. Mutations and translocations in the JAK genes leading to constitutively active JAK proteins are associated with a variety of hematopoietic malignancies, including the myeloproliferative disorders (JAK2), acute lymphoblastic leukemia (JAK2), acute myeloid leukemia (JAK2, JAK1), acute megakaryoblastic leukemia (JAK2, JAK3) and T-cell precursor acute lymphoblastic leukemia (JAK1). In contrast, loss-of-function mutations of JAK3 and TYK2 lead to immunodeficiency. The role of JAKs as therapeutic targets is starting to expand, as more insights into their structure and activation mechanisms become available.
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