[HTML][HTML] Functional regulation of L-type calcium channels via protein kinase A-mediated phosphorylation of the β2 subunit
M Bünemann, BL Gerhardstein, T Gao… - Journal of Biological …, 1999 - ASBMB
Activation of protein kinase A (PKA) through the β-adrenergic receptor pathway is crucial for
the positive regulation of cardiac L-type currents; however it is still unclear which
phosphorylation events cause the robust regulation of channel function. In order to study
whether or not the recently identified PKA phosphorylation sites on the β 2 subunit are of
functional significance, we coexpressed wild-type (WT) or mutant β 2 subunits in tsA-201
cells together with an α 1C subunit, α 1C Δ1905, that lacked the C-terminal 265 amino acids …
the positive regulation of cardiac L-type currents; however it is still unclear which
phosphorylation events cause the robust regulation of channel function. In order to study
whether or not the recently identified PKA phosphorylation sites on the β 2 subunit are of
functional significance, we coexpressed wild-type (WT) or mutant β 2 subunits in tsA-201
cells together with an α 1C subunit, α 1C Δ1905, that lacked the C-terminal 265 amino acids …