Caffeine-induced disturbances of early neurogenesis in whole mouse embryo cultures
S Marret, P Gressens, G Van-Maele-Fabry, J Picard… - Brain research, 1997 - Elsevier
Brain research, 1997•Elsevier
In toto mouse embryos were cultivated at embryonic day 8.5 for 26 h with 105, 310 or 620
μM caffeine; 105–310 μM correspond to concentrations transferred by the placenta of heavy
caffeine consumers. Failure of neural tube closure, excessive proliferation of neuroepithelial
cells and premature evagination of telencephalic vesicles were present in 50% of treated
embryos. When reaching the embryonic neural tube before neuronal migration, caffeine
regionally modifies the schedule and/or rate of neural cell proliferation.
μM caffeine; 105–310 μM correspond to concentrations transferred by the placenta of heavy
caffeine consumers. Failure of neural tube closure, excessive proliferation of neuroepithelial
cells and premature evagination of telencephalic vesicles were present in 50% of treated
embryos. When reaching the embryonic neural tube before neuronal migration, caffeine
regionally modifies the schedule and/or rate of neural cell proliferation.
In toto mouse embryos were cultivated at embryonic day 8.5 for 26 h with 105, 310 or 620 μM caffeine; 105–310 μM correspond to concentrations transferred by the placenta of heavy caffeine consumers. Failure of neural tube closure, excessive proliferation of neuroepithelial cells and premature evagination of telencephalic vesicles were present in 50% of treated embryos. When reaching the embryonic neural tube before neuronal migration, caffeine regionally modifies the schedule and/or rate of neural cell proliferation.
Elsevier