Several reports have highlighted the potential roles for the VIP-related neuropeptides in
regeneration/neuroprotection after brain or nerve injuries. We previously reported that
peripheral inflammation worsened ibotenate-induced cystic white matter lesions. Because
VIP is also known as an immunomodulator, we wonder if VIP could also limit the deleterious
effects of local inflammation. Therefore, we first tested the effects of peripheral IL-1β on VIP
and PACAP central production. Second, we observed that cox-2 activation by IL-1β was …