Glycogen synthase kinase-3 (GSK-3) isoforms, GSK-3α and GSK-3β, are serine/threonine
kinases involved in numerous cellular processes and diverse diseases, including Alzheimer
disease, cancer, and diabetes. GSK-3 isoforms function redundantly in some settings, while,
in others, they exhibit distinct activities. Despite intensive investigation into the physiological
roles of GSK-3 isoforms, the basis for their differential activities remains unresolved. A more
comprehensive understanding of the mechanistic basis for GSK-3 isoform-specific functions …