Augmentation of cocaine hyperactivity in rats by systemic ghrelin
PJ Wellman, KW Davis, JR Nation - Regulatory peptides, 2005 - Elsevier
The feeding-relevant pathway by which food deprivation (FD) augments cocaine action is
unknown. Systemic administration of the 28 amino acid acylated peptide ghrelin (1–10
nmol) increases food intake in rats and circulating levels of rat ghrelin are up-regulated by
FD. The present experiment examined the impact of ghrelin or vehicle pretreatment on the
locomotion and stereotypy induced by systemic cocaine hydrochloride. Male Sprague–
Dawley rats were pretreated at− 60 min with 0 or 5 nmol rat ghrelin (IP) and then injected …
unknown. Systemic administration of the 28 amino acid acylated peptide ghrelin (1–10
nmol) increases food intake in rats and circulating levels of rat ghrelin are up-regulated by
FD. The present experiment examined the impact of ghrelin or vehicle pretreatment on the
locomotion and stereotypy induced by systemic cocaine hydrochloride. Male Sprague–
Dawley rats were pretreated at− 60 min with 0 or 5 nmol rat ghrelin (IP) and then injected …