A close interplay exists between the serotonergic and dopaminergic neuronal systems both
at the anatomical and functional level. It has long been known, at least in mammals, that the
central serotonergic system modulates the activity of dopaminergic neurons in both the
nigrostriatal pathway and ventral tegmental area. Since the discovery that reserpine and
amphetamine induce symptoms in man that resemble those associated with depression and
schizophrenia respectively, much attention has focussed on the development of drugs which …