[HTML][HTML] Intracellular Shuttling and Mitochondrial Function of Thioredoxin-interacting Protein 2
G Saxena, J Chen, A Shalev - Journal of Biological Chemistry, 2010 - ASBMB
The thioredoxin-interacting protein TXNIP is a ubiquitously expressed redox protein that
promotes apoptosis. Recently, we found that TXNIP deficiency protects against type 1 and 2
diabetes by inhibiting beta cell apoptosis and maintaining pancreatic beta cell mass,
indicating that TXNIP plays a key role in beta cell biology. However, very little is known
about the intracellular localization and function of TXNIP, and although TXNIP has been
thought to be a cytoplasmic protein, our immunohistochemistry studies in beta cells …
promotes apoptosis. Recently, we found that TXNIP deficiency protects against type 1 and 2
diabetes by inhibiting beta cell apoptosis and maintaining pancreatic beta cell mass,
indicating that TXNIP plays a key role in beta cell biology. However, very little is known
about the intracellular localization and function of TXNIP, and although TXNIP has been
thought to be a cytoplasmic protein, our immunohistochemistry studies in beta cells …
