Gene expression profile of Mycobacterium tuberculosis in a non-replicating state
DGN Muttucumaru, G Roberts, J Hinds, RA Stabler… - Tuberculosis, 2004 - Elsevier
Mycobacterium tuberculosis is able to persist in the human host for decades in an
apparently dormant state where it is presumed to reside in an hypoxic environment. This can
be mimicked by the Wayne culture model in which progressive oxygen depletion causes the
bacteria to shift into a non-replicating state. We investigated global gene expression in
aerobic (roller), microaerophilic (NRP1) and anaerobic (NRP2) cultures. A number of genes
were significantly up-regulated as compared to aerobic culture; 178 in NRP1, 210 in NRP2 …
apparently dormant state where it is presumed to reside in an hypoxic environment. This can
be mimicked by the Wayne culture model in which progressive oxygen depletion causes the
bacteria to shift into a non-replicating state. We investigated global gene expression in
aerobic (roller), microaerophilic (NRP1) and anaerobic (NRP2) cultures. A number of genes
were significantly up-regulated as compared to aerobic culture; 178 in NRP1, 210 in NRP2 …