Effect of Growth State on Transcription Levels of Genes Encoding Major Secreted Antigens of Mycobacterium tuberculosis in the Mouse Lung
L Shi, R North, ML Gennaro - Infection and immunity, 2004 - Am Soc Microbiol
L Shi, R North, ML Gennaro
Infection and immunity, 2004•Am Soc MicrobiolArrest of the multiplication of Mycobacterium tuberculosis caused by expression of adaptive
immunity in mouse lung was accompanied by a 10-to 20-fold decrease in levels of mRNAs
encoding the secreted Ag85 complex and 38-kDa lipoprotein. esat-6 mRNA levels were
high throughout infection. The data imply that multiplying and nonreplicating tubercle bacilli
have different antigen compositions.
immunity in mouse lung was accompanied by a 10-to 20-fold decrease in levels of mRNAs
encoding the secreted Ag85 complex and 38-kDa lipoprotein. esat-6 mRNA levels were
high throughout infection. The data imply that multiplying and nonreplicating tubercle bacilli
have different antigen compositions.
Abstract
Arrest of the multiplication of Mycobacterium tuberculosis caused by expression of adaptive immunity in mouse lung was accompanied by a 10- to 20-fold decrease in levels of mRNAs encoding the secreted Ag85 complex and 38-kDa lipoprotein. esat-6 mRNA levels were high throughout infection. The data imply that multiplying and nonreplicating tubercle bacilli have different antigen compositions.
American Society for Microbiology