Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme …
BL Carlson, PT Grogan, AC Mladek… - International Journal of …, 2009 - Elsevier
PURPOSE: Concurrent temozolomide (TMZ) and radiation therapy (RT) followed by
adjuvant TMZ is standard treatment for patients with glioblastoma multiforme (GBM),
although the relative contribution of concurrent versus adjuvant TMZ is unknown. In this
study, the efficacy of TMZ/RT was tested with a panel of 20 primary GBM xenografts.
METHODS AND MATERIALS: Mice with intracranial xenografts were treated with TMZ, RT,
TMZ/RT, or placebo. Survival ratio for a given treatment/line was defined as the ratio of …
adjuvant TMZ is standard treatment for patients with glioblastoma multiforme (GBM),
although the relative contribution of concurrent versus adjuvant TMZ is unknown. In this
study, the efficacy of TMZ/RT was tested with a panel of 20 primary GBM xenografts.
METHODS AND MATERIALS: Mice with intracranial xenografts were treated with TMZ, RT,
TMZ/RT, or placebo. Survival ratio for a given treatment/line was defined as the ratio of …