Prevalence and mortality make cancer a health challenge in need of effective and better
tolerated therapeutic approaches, with tumor angiogenesis identified as a promising target
for drug development. The epoxygenase products, the epoxyeicosatrienoic acids, are pro-
angiogenic, and down-regulation of their biosynthesis by peroxisomal proliferator-activated
receptor α (PPARα) ligands reduces tumor angiogenesis and growth. Endothelial cells
lacking a Cyp2c44 epoxygenase, a PPARα target, show reduced proliferative and …