Cell division during embryogenesis plays a crucial role in the formation of the nervous
system. During this developmental process, proliferating neural precursor cells commit to a
neuronal fate and, as a consequence, undergo terminal mitosis and adopt a neuronal
phenotype. A key cell cycle regulator, the tumor suppressor protein, retinoblastoma (Rb), is
involved in both terminal mitosis and neuronal differentiation. Neural development is a
complex process involving cell proliferation, cell fate determination and differentiation, as …