[HTML][HTML] Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl …
M Oppermann, M Mack, AEI Proudfoot… - Journal of Biological …, 1999 - ASBMB
The binding of CC chemokines to CC chemokine receptor 5 (CCR5) triggers cellular
responses that, generally, are only transient in nature. To explore the potential role of G
protein-coupled receptor kinases (GRKs) in the regulation of CCR5, we performed
phosphorylation experiments in a rat basophilic leukemia cell line stably expressing CCR5.
The ability of various CCR5 ligands to stimulate calcium mobilization in these cells
correlated with their ability to induce receptor phosphorylation, desensitization …
responses that, generally, are only transient in nature. To explore the potential role of G
protein-coupled receptor kinases (GRKs) in the regulation of CCR5, we performed
phosphorylation experiments in a rat basophilic leukemia cell line stably expressing CCR5.
The ability of various CCR5 ligands to stimulate calcium mobilization in these cells
correlated with their ability to induce receptor phosphorylation, desensitization …