Inhibitors of mitochondrial complex I attenuate the accumulation of hypoxia-inducible factor-1 during hypoxia in Hep3B cells
FH Agani, P Pichiule, JC Chavez… - … and Physiology Part A …, 2002 - Elsevier
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that regulates
transcriptional activation of several genes that are responsive to oxygen lack, including
erythropoietin, vascular endothelial growth factor, various glycolytic enzymes and the GLUT-
1 glucose transporter. Because mitochondria have been postulated to be involved in the
regulation of HIF-1, we tested the effects of mitochondrial electron transport chain complex I
inhibitors, rotenone and 1-methyl-4-phenylpiridinium (MPP+), on hypoxic-induced …
transcriptional activation of several genes that are responsive to oxygen lack, including
erythropoietin, vascular endothelial growth factor, various glycolytic enzymes and the GLUT-
1 glucose transporter. Because mitochondria have been postulated to be involved in the
regulation of HIF-1, we tested the effects of mitochondrial electron transport chain complex I
inhibitors, rotenone and 1-methyl-4-phenylpiridinium (MPP+), on hypoxic-induced …