[HTML][HTML] Stabilization of hypoxia-inducible factor-1α protein in hypoxia occurs independently of mitochondrial reactive oxygen species production
The transcription factor hypoxia-inducible factor-1α (HIF-1α) is a master regulator of the
cellular response to low oxygen. HIF-1α protein accumulates in hypoxia due to inhibition of
prolyl hydroxylase enzymes, which under normoxic conditions use molecular oxygen to
hydroxylate HIF-1α on two conserved proline residues (Pro 402 and Pro 564), thus targeting
the protein for 26 S proteasome-dependent degradation. A functional mitochondrial electron
transport chain is known to be necessary for HIF-1α stabilization in hypoxia. It has been …
cellular response to low oxygen. HIF-1α protein accumulates in hypoxia due to inhibition of
prolyl hydroxylase enzymes, which under normoxic conditions use molecular oxygen to
hydroxylate HIF-1α on two conserved proline residues (Pro 402 and Pro 564), thus targeting
the protein for 26 S proteasome-dependent degradation. A functional mitochondrial electron
transport chain is known to be necessary for HIF-1α stabilization in hypoxia. It has been …