The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia
FH Agani, P Pichiule, JC Chavez… - Journal of Biological …, 2000 - ASBMB
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that regulates
transcriptional activation of several genes responsive to the lack of oxygen, including
erythropoietin, vascular endothelial growth factor, glycolytic enzymes, and glucose
transporters. Because the involvement of mitochondria in the regulation of HIF-1 has been
postulated, we tested the effects of mitochondrial electron transport chain deficiency on HIF-
1 protein expression and DNA binding in hypoxic cells. The neurotoxin 1-methyl-4-phenyl-1 …
transcriptional activation of several genes responsive to the lack of oxygen, including
erythropoietin, vascular endothelial growth factor, glycolytic enzymes, and glucose
transporters. Because the involvement of mitochondria in the regulation of HIF-1 has been
postulated, we tested the effects of mitochondrial electron transport chain deficiency on HIF-
1 protein expression and DNA binding in hypoxic cells. The neurotoxin 1-methyl-4-phenyl-1 …
