Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia
J Li, B Gran, GX Zhang, ES Ventura, I Siglienti… - Journal of the …, 2003 - Elsevier
IL-23 and IL-12 are functionally related heterodimeric cytokines that share the IL-12p40
subunit. IL-23 and IL-12 function through heterodimeric receptors, which share the IL-12Rβ1
subunit. Production of IL-23, a heterodimer of IL-12p40 and IL-23p19, by CNS antigen-
presenting cells (APC) is critical for susceptibility to experimental autoimmune
encephalomyelitis (EAE), the animal model for multiple sclerosis (MS). We report that the
expression of IL-23p19 mRNA is highly induced by stimulation with IFN-γ and LPS in adult …
subunit. IL-23 and IL-12 function through heterodimeric receptors, which share the IL-12Rβ1
subunit. Production of IL-23, a heterodimer of IL-12p40 and IL-23p19, by CNS antigen-
presenting cells (APC) is critical for susceptibility to experimental autoimmune
encephalomyelitis (EAE), the animal model for multiple sclerosis (MS). We report that the
expression of IL-23p19 mRNA is highly induced by stimulation with IFN-γ and LPS in adult …