Systemic infections and inflammation affect chronic neurodegeneration
VH Perry, C Cunningham, C Holmes - Nature Reviews Immunology, 2007 - nature.com
VH Perry, C Cunningham, C Holmes
Nature Reviews Immunology, 2007•nature.comIt is well known that systemic infections cause flare-ups of disease in individuals with asthma
and rheumatoid arthritis, and that relapses in multiple sclerosis can often be associated with
upper respiratory-tract infections. Here we review evidence to support our hypothesis that in
chronic neurodegenerative diseases such as Alzheimer's disease, with an ongoing innate
immune response in the brain, systemic infections and inflammation can cause acute
exacerbations of symptoms and drive the progression of neurodegeneration.
and rheumatoid arthritis, and that relapses in multiple sclerosis can often be associated with
upper respiratory-tract infections. Here we review evidence to support our hypothesis that in
chronic neurodegenerative diseases such as Alzheimer's disease, with an ongoing innate
immune response in the brain, systemic infections and inflammation can cause acute
exacerbations of symptoms and drive the progression of neurodegeneration.
Abstract
It is well known that systemic infections cause flare-ups of disease in individuals with asthma and rheumatoid arthritis, and that relapses in multiple sclerosis can often be associated with upper respiratory-tract infections. Here we review evidence to support our hypothesis that in chronic neurodegenerative diseases such as Alzheimer's disease, with an ongoing innate immune response in the brain, systemic infections and inflammation can cause acute exacerbations of symptoms and drive the progression of neurodegeneration.
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