Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia
Nature neuroscience, 2009•nature.com
In Alzheimer's disease, microglia cluster around β-amyloid deposits, suggesting that these
cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed
two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly
complete ablation of microglia was achieved for up to 4 weeks after ganciclovir application.
Neither amyloid plaque formation and maintenance nor amyloid-associated neuritic
dystrophy depended on the presence of microglia.
cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed
two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly
complete ablation of microglia was achieved for up to 4 weeks after ganciclovir application.
Neither amyloid plaque formation and maintenance nor amyloid-associated neuritic
dystrophy depended on the presence of microglia.
Abstract
In Alzheimer's disease, microglia cluster around β-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was achieved for up to 4 weeks after ganciclovir application. Neither amyloid plaque formation and maintenance nor amyloid-associated neuritic dystrophy depended on the presence of microglia.
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