Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells
EG Van Meir, PJ Polverini, VR Chazin, HJ Su Huang… - Nature Genetics, 1994 - nature.com
Nature Genetics, 1994•nature.com
The earliest genetic alteration in human astrocytoma progression is mutation of the p53
tumour suppressor gene, while one of the earliest phenotypic changes is the stimulation of
neovascularization. Here, we tested the role of p53 in the angiogenic process by introducing
a tetracycline-regulated wild type p53 gene into null glioblastoma cells. The parental cells
expressed strong angiogenic activity while upon induction of wild type, but not mutant, p53
expression, the cells secreted a factor able to neutralize the angiogenicity of the factors …
tumour suppressor gene, while one of the earliest phenotypic changes is the stimulation of
neovascularization. Here, we tested the role of p53 in the angiogenic process by introducing
a tetracycline-regulated wild type p53 gene into null glioblastoma cells. The parental cells
expressed strong angiogenic activity while upon induction of wild type, but not mutant, p53
expression, the cells secreted a factor able to neutralize the angiogenicity of the factors …
Abstract
The earliest genetic alteration in human astrocytoma progression is mutation of the p53 tumour suppressor gene, while one of the earliest phenotypic changes is the stimulation of neovascularization. Here, we tested the role of p53 in the angiogenic process by introducing a tetracycline-regulated wild type p53 gene into null glioblastoma cells. The parental cells expressed strong angiogenic activity while upon induction of wild type, but not mutant, p53 expression, the cells secreted a factor able to neutralize the angiogenicity of the factors produced by the parental cells as well as of basic fibroblast growth factor.
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