TCF transcription factors, mediators of Wnt-signaling in development and cancer
M van Noort, H Clevers - Developmental biology, 2002 - Elsevier
M van Noort, H Clevers
Developmental biology, 2002•ElsevierThe Wnt-signaling cascade plays critical roles in embryonic patterning, cell fate
determination, and tissue homeostasis. When secreted Wnt factors bind to their receptors, a
set of biochemical changes is set in motion, ultimately resulting in the accumulation of ß-
catenin and its translocation to the nucleus. In the nucleus, ß-catenin binds to members of
the TCF/LEF family of transcription factors, the most downstream components of the
Wntsignaling pathway. Here, an overview is given of this tightly regulated cascade, with …
determination, and tissue homeostasis. When secreted Wnt factors bind to their receptors, a
set of biochemical changes is set in motion, ultimately resulting in the accumulation of ß-
catenin and its translocation to the nucleus. In the nucleus, ß-catenin binds to members of
the TCF/LEF family of transcription factors, the most downstream components of the
Wntsignaling pathway. Here, an overview is given of this tightly regulated cascade, with …
The Wnt-signaling cascade plays critical roles in embryonic patterning, cell fate determination, and tissue homeostasis. When secreted Wnt factors bind to their receptors, a set of biochemical changes is set in motion, ultimately resulting in the accumulation of ß-catenin and its translocation to the nucleus. In the nucleus, ß-catenin binds to members of the TCF/LEF family of transcription factors, the most downstream components of the Wntsignaling pathway. Here, an overview is given of this tightly regulated cascade, with particular emphasis on events that take place in the nucleus.
Elsevier