[HTML][HTML] Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc
The tumor suppressor protein ARF (alternate reading frame) inhibits MDM2 to stabilize and
activate the functions of p53. Here we provide evidence for an additional activity of ARF that
attenuates cell cycle progression independently of p53 activation. We show that ARF
interacts with c-Myc independently of MDM2 or p53. Consequently, ARF relocalizes c-Myc
from the nucleoplasm to the nucleolus. Binding and relocalization by ARF correlate with an
inhibition of the c-Myc-activated transcription in both p53-positive and-negative cells. Using …
activate the functions of p53. Here we provide evidence for an additional activity of ARF that
attenuates cell cycle progression independently of p53 activation. We show that ARF
interacts with c-Myc independently of MDM2 or p53. Consequently, ARF relocalizes c-Myc
from the nucleoplasm to the nucleolus. Binding and relocalization by ARF correlate with an
inhibition of the c-Myc-activated transcription in both p53-positive and-negative cells. Using …