[HTML][HTML] Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and β1 integrin and for tumor cell proliferation and …
Insulin-like growth factor (IGF)-I regulates a mutually exclusive interaction of PP2A and β1
integrin with the WD repeat scaffolding protein RACK1. This interaction is required for the
integration of IGF-I receptor (IGF-IR) and adhesion signaling. Here we investigated the
nature of the binding site for PP2A and β1 integrin in RACK1. A WD7 deletion mutant of
RACK1 did not associate with PP2A but retained some interaction with β1 integrin, whereas
a WD6/WD7 mutant lost the ability to bind to both PP2A and β1 integrin. Using immobilized …
integrin with the WD repeat scaffolding protein RACK1. This interaction is required for the
integration of IGF-I receptor (IGF-IR) and adhesion signaling. Here we investigated the
nature of the binding site for PP2A and β1 integrin in RACK1. A WD7 deletion mutant of
RACK1 did not associate with PP2A but retained some interaction with β1 integrin, whereas
a WD6/WD7 mutant lost the ability to bind to both PP2A and β1 integrin. Using immobilized …