Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial
Context The need for lung protection is universally accepted, but the optimal level of positive
end-expiratory pressure (PEEP) in patients with acute lung injury (ALI) or acute respiratory
distress syndrome remains debated. Objective To compare the effect on outcome of a
strategy for setting PEEP aimed at increasing alveolar recruitment while limiting
hyperinflation to one aimed at minimizing alveolar distension in patients with ALI. Design,
Setting, and Patients A multicenter randomized controlled trial of 767 adults (mean [SD] age …
end-expiratory pressure (PEEP) in patients with acute lung injury (ALI) or acute respiratory
distress syndrome remains debated. Objective To compare the effect on outcome of a
strategy for setting PEEP aimed at increasing alveolar recruitment while limiting
hyperinflation to one aimed at minimizing alveolar distension in patients with ALI. Design,
Setting, and Patients A multicenter randomized controlled trial of 767 adults (mean [SD] age …