Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial

P Taccone, A Pesenti, R Latini, F Polli, F Vagginelli… - Jama, 2009 - jamanetwork.com
Context Post hoc analysis of a previous trial has suggested that prone positioning may
improve survival in patients with severe hypoxemia and with acute respiratory distress
syndrome (ARDS). Objective To assess possible outcome benefits of prone positioning in
patients with moderate and severe hypoxemia who are affected by ARDS. Design, Setting,
and Patients The Prone-Supine II Study, a multicenter, unblinded, randomized controlled
trial conducted in 23 centers in Italy and 2 in Spain. Patients were 342 adults with ARDS …