Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury
CS Calfee, LB Ware, DV Glidden, MD Eisner… - Critical care …, 2011 - journals.lww.com
Objective: Multiple single biomarkers have been associated with poor outcomes in acute
lung injury; however, no single biomarker has sufficient discriminating power to clearly
indicate prognosis. Using both derivation and replication cohorts, we tested novel risk
reclassification methods to determine whether measurement of multiple plasma biomarkers
at the time of acute lung injury diagnosis would improve mortality prediction in acute lung
injury. Design: Analysis of plasma biomarker levels and prospectively collected clinical data …
lung injury; however, no single biomarker has sufficient discriminating power to clearly
indicate prognosis. Using both derivation and replication cohorts, we tested novel risk
reclassification methods to determine whether measurement of multiple plasma biomarkers
at the time of acute lung injury diagnosis would improve mortality prediction in acute lung
injury. Design: Analysis of plasma biomarker levels and prospectively collected clinical data …