Cytokine–serotonin interaction through IDO: a neurodegeneration hypothesis of depression
AM Myint, YK Kim - Medical hypotheses, 2003 - Elsevier
There are different theories and hypotheses related to the aetiology of depression. The
interaction between brain 5-HT level and the activity of its autoreceptors plays a role in mood
changes and depression. In major depression, activation of the inflammatory response
system (IRS) and, increased concentrations of proinflammatory cytokines, prostaglandin E2
and negative immuno-regulatory cytokines in peripheral blood have been reported.
Recently, pro-inflammatory cytokines have been found to have profound effects on the …
interaction between brain 5-HT level and the activity of its autoreceptors plays a role in mood
changes and depression. In major depression, activation of the inflammatory response
system (IRS) and, increased concentrations of proinflammatory cytokines, prostaglandin E2
and negative immuno-regulatory cytokines in peripheral blood have been reported.
Recently, pro-inflammatory cytokines have been found to have profound effects on the …