[PDF][PDF] BRAF Gene Is Somatically Mutated but Does Not Make a Major Contribution to Malignant Melanoma Susceptibility: The Italian Melanoma Intergroup Study
M Casula, M Colombino, MP Satta… - Journal of clinical …, 2004 - researchgate.net
Journal of clinical oncology, 2004•researchgate.net
Purpose Oncogenic activation of the BRAF gene has been demonstrated to be involved in
the pathogenesis of malignant melanoma (MM). In this study, we investigated the
contribution of BRAF to melanoma susceptibility, also making a comparison with frequency
of CDKN2A germline mutations in MM patients from different areas in Italy.
the pathogenesis of malignant melanoma (MM). In this study, we investigated the
contribution of BRAF to melanoma susceptibility, also making a comparison with frequency
of CDKN2A germline mutations in MM patients from different areas in Italy.
Purpose
Oncogenic activation of the BRAF gene has been demonstrated to be involved in the pathogenesis of malignant melanoma (MM). In this study, we investigated the contribution of BRAF to melanoma susceptibility, also making a comparison with frequency of CDKN2A germline mutations in MM patients from different areas in Italy.
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