Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice
T Van Es, GHM Van Puijvelde, OH Ramos… - Biochemical and …, 2009 - Elsevier
T Van Es, GHM Van Puijvelde, OH Ramos, FME Segers, LA Joosten, WB van Den Berg…
Biochemical and biophysical research communications, 2009•ElsevierAtherosclerosis is an inflammatory disease characterized by the influx of macrophages and
T cells and IL-17 may connect innate and adaptive immune responses involved in
atherogenesis. We investigated the role of IL-17 receptor signaling in atherosclerosis and
transplanted LDLr deficient recipient mice with IL-17R deficient bone marrow. Induction of
atherosclerosis by Western-type diet induced a 46% reduction in lesion size in the aortic root
and the plaque composition revealed no significant changes in collagen content and …
T cells and IL-17 may connect innate and adaptive immune responses involved in
atherogenesis. We investigated the role of IL-17 receptor signaling in atherosclerosis and
transplanted LDLr deficient recipient mice with IL-17R deficient bone marrow. Induction of
atherosclerosis by Western-type diet induced a 46% reduction in lesion size in the aortic root
and the plaque composition revealed no significant changes in collagen content and …
Atherosclerosis is an inflammatory disease characterized by the influx of macrophages and T cells and IL-17 may connect innate and adaptive immune responses involved in atherogenesis. We investigated the role of IL-17 receptor signaling in atherosclerosis and transplanted LDLr deficient recipient mice with IL-17R deficient bone marrow. Induction of atherosclerosis by Western-type diet induced a 46% reduction in lesion size in the aortic root and the plaque composition revealed no significant changes in collagen content and neutrophil counts, but a reduction in mast cell number and an increase in macrophage number. In addition, we observed a decrease in anti-oxLDL antibodies of the IgG class upon IL-17R BMT, while introduction of IL-17R deficient bone marrow resulted in a reduced IL-6 production and an increased IL-10 production. In conclusion, signaling via the IL-17 receptor in bone marrow derived cells enhances the process of atherosclerosis.
Elsevier