Natural regulatory T cells control the development of atherosclerosis in mice

H Ait-Oufella, BL Salomon, S Potteaux… - Nature medicine, 2006 - nature.com
H Ait-Oufella, BL Salomon, S Potteaux, AKL Robertson, P Gourdy, J Zoll, R Merval…
Nature medicine, 2006nature.com
Atherosclerosis is an immunoinflammatory disease elicited by accumulation of lipids in the
artery wall and leads to myocardial infarction and stroke,. Here, we show that naturally
arising CD4+ CD25+ regulatory T cells, which actively maintain immunological tolerance to
self and nonself antigens,, are powerful inhibitors of atherosclerosis in several mouse
models. These results provide new insights into the immunopathogenesis of atherosclerosis
and could lead to new therapeutic approaches that involve immune modulation using …
Abstract
Atherosclerosis is an immunoinflammatory disease elicited by accumulation of lipids in the artery wall and leads to myocardial infarction and stroke,. Here, we show that naturally arising CD4+CD25+ regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens,, are powerful inhibitors of atherosclerosis in several mouse models. These results provide new insights into the immunopathogenesis of atherosclerosis and could lead to new therapeutic approaches that involve immune modulation using regulatory T cells.
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