Mutant SOD1 G93A microglia have an inflammatory phenotype and elevated production of MCP-1

SA Sargsyan, DJ Blackburn, SC Barber, PN Monk… - …, 2009 - journals.lww.com
The inflammatory response in amyotrophic lateral sclerosis (ALS) is well documented but
the underlying cellular mechanisms have not been fully elucidated. We report that microglia
isolated from the mutant human superoxide dismutase 1 (SOD1) G93A transgenic mouse
model of ALS have an increased response to the inflammatory stimulus, lipopolysaccharide.
Cell surface area and F4/80 surface marker, both indicators of cell activation, are increased
relative to transgenic wild-type human SOD1 microglia. Monocyte chemoattractant protein-1 …