Direct polyclonal activation of human B lymphocytes by the acquired immune deficiency syndrome virus
SM Schnittman, HC Lane, SE Higgins, T Folks… - Science, 1986 - science.org
When B lymphocytes from normal human peripheral blood were incubated for 1 hour with
the retrovirus that causes the acquired immune deficiency syndrome (AIDS), the B cells
showed marked proliferation and differentiation. Proliferative responses to the virus peaked
on day 4 and appeared to be independent of accessory cells. This finding was repeated with
three separate viral isolates, one of which was from a patient from Zaire. The magnitude of
the observed responses was comparable to that seen with standard polyclonal B-cell …
the retrovirus that causes the acquired immune deficiency syndrome (AIDS), the B cells
showed marked proliferation and differentiation. Proliferative responses to the virus peaked
on day 4 and appeared to be independent of accessory cells. This finding was repeated with
three separate viral isolates, one of which was from a patient from Zaire. The magnitude of
the observed responses was comparable to that seen with standard polyclonal B-cell …
When B lymphocytes from normal human peripheral blood were incubated for 1 hour with the retrovirus that causes the acquired immune deficiency syndrome (AIDS), the B cells showed marked proliferation and differentiation. Proliferative responses to the virus peaked on day 4 and appeared to be independent of accessory cells. This finding was repeated with three separate viral isolates, one of which was from a patient from Zaire. The magnitude of the observed responses was comparable to that seen with standard polyclonal B-cell activators. This phenomenon may be at least partially responsible for the polyclonal B-cell activation seen in patients with AIDS.
AAAS