Sirtuins catalyze NAD+-dependent protein deacetylation and are critical regulators of
transcription, apoptosis, metabolism, and aging. There are seven human sirtuins (SIRT1–7),
and SIRT1 has been implicated as a key mediator of the pathways downstream of calorie
restriction that have been shown to delay the onset and reduce the incidence of age-related
diseases such as type 2 diabetes. Increasing SIRT1 activity, either by transgenic
overexpression of the Sirt1 gene in mice or by pharmacological activation by small molecule …