Cerebral interleukin-15 shows upregulation and beneficial effects in experimental autoimmune encephalomyelitis
X Wu, W Pan, Y He, H Hsuchou, AJ Kastin - Journal of neuroimmunology, 2010 - Elsevier
Interleukin (IL)-15 can cross the blood–brain barrier to act on its specific brain receptor
(IL15Rα) and co-receptors. The important roles of neuronal IL15 and IL15Rα in experimental
autoimmune encephalomeylitis (EAE) are suggested by the upregulation of IL15Rα mRNA
in different regions of the brain and spinal cord, and by double-labeling
immunohistochemistry showing neuronal localization of IL15 and IL15Rα in different
neurons. Contrary to expectations, IL15 treatment lessened EAE severity. IL15 knockout …
(IL15Rα) and co-receptors. The important roles of neuronal IL15 and IL15Rα in experimental
autoimmune encephalomeylitis (EAE) are suggested by the upregulation of IL15Rα mRNA
in different regions of the brain and spinal cord, and by double-labeling
immunohistochemistry showing neuronal localization of IL15 and IL15Rα in different
neurons. Contrary to expectations, IL15 treatment lessened EAE severity. IL15 knockout …