Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
JP Sheridan, SA Marsters, RM Pitti, A Gurney… - Science, 1997 - science.org
JP Sheridan, SA Marsters, RM Pitti, A Gurney, M Skubatch, D Baldwin, L Ramakrishnan…
Science, 1997•science.orgTRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid
apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional
TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained
a cytoplasmic death domain and induced apoptosis much like DR4. The receptor
designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored
cell surface protein. DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a …
apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional
TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained
a cytoplasmic death domain and induced apoptosis much like DR4. The receptor
designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored
cell surface protein. DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a …
TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained a cytoplasmic death domain and induced apoptosis much like DR4. The receptor designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored cell surface protein. DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli.
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