Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-γ-dependent suppression of subcutaneous tumor growth
K Takeda, MJ Smyth, E Cretney, Y Hayakawa… - Cellular …, 2001 - Elsevier
Natural killer (NK) cells and interferon-(IFN) γ have been implicated in immune surveillance
against tumor development. Here we show tumor necrosis factor-related apoptosis-inducing
ligand (TRAIL), which is a type II membrane protein belonging to the TNF family and plays a
critical role in the NK cell-mediated and IFN-γ-dependent suppression of subcutaneous
growth of TRAIL-sensitive tumors. Administration of a neutralizing monoclonal antibody
against TRAIL promoted outgrowth of subcutaneously inoculated TRAIL-sensitive tumors …
against tumor development. Here we show tumor necrosis factor-related apoptosis-inducing
ligand (TRAIL), which is a type II membrane protein belonging to the TNF family and plays a
critical role in the NK cell-mediated and IFN-γ-dependent suppression of subcutaneous
growth of TRAIL-sensitive tumors. Administration of a neutralizing monoclonal antibody
against TRAIL promoted outgrowth of subcutaneously inoculated TRAIL-sensitive tumors …