Mammalian target of rapamycin and caspase inhibitors in polycystic kidney disease
CL Edelstein - Clinical Journal of the American Society of …, 2008 - journals.lww.com
One of the most important abnormalities of the tubular epithelial cells lining the cysts as well
as noncystic tubular epithelium is a disturbance in the balance between tubular cell
proliferation and apoptosis. Activation of the mammalian target of rapamycin signaling
pathway results in increased cell proliferation. Recent studies suggested abnormalities of
the mammalian target of rapamycin signaling pathway in polycystic kidney disease.
Mammalian target of rapamycin inhibition with sirolimus or everolimus results in attenuation …
as noncystic tubular epithelium is a disturbance in the balance between tubular cell
proliferation and apoptosis. Activation of the mammalian target of rapamycin signaling
pathway results in increased cell proliferation. Recent studies suggested abnormalities of
the mammalian target of rapamycin signaling pathway in polycystic kidney disease.
Mammalian target of rapamycin inhibition with sirolimus or everolimus results in attenuation …