[HTML][HTML] Sirt-1 is required for the inhibition of apoptosis and inflammatory responses in human tenocytes
F Busch, A Mobasheri, P Shayan, R Stahlmann… - Journal of Biological …, 2012 - ASBMB
Background: Sirt-1 has been linked to transcriptional silencing and appears to play a key
role in inflammation. Results: Transfection of tenocytes with antisense oligonucleotides
against Sirt-1-induced inflammation and apoptosis. Conclusion: Sirt-1 can regulate p53 and
NF-κB activity via deacetylation. Significance: Down-regulation of Sirt-1 by mRNA
interference abrogated the effect of resveratrol on p53 and NF-κB suppression.
role in inflammation. Results: Transfection of tenocytes with antisense oligonucleotides
against Sirt-1-induced inflammation and apoptosis. Conclusion: Sirt-1 can regulate p53 and
NF-κB activity via deacetylation. Significance: Down-regulation of Sirt-1 by mRNA
interference abrogated the effect of resveratrol on p53 and NF-κB suppression.