Adaptive immune responses in acute and chronic hepatitis C virus infection
The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant
cause of human illness and death globally. Recent studies have yielded important insights
into immunity to HCV, in particular revealing the central role of T cells in viral control and
clearance. Other key features of adaptive immune responses remain obscure, including
mechanisms by which T cells control HCV replication, the role of antibodies in conferring
protection and how cellular and humoral immunity are subverted in persistent infection.
cause of human illness and death globally. Recent studies have yielded important insights
into immunity to HCV, in particular revealing the central role of T cells in viral control and
clearance. Other key features of adaptive immune responses remain obscure, including
mechanisms by which T cells control HCV replication, the role of antibodies in conferring
protection and how cellular and humoral immunity are subverted in persistent infection.
Abstract
The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant cause of human illness and death globally. Recent studies have yielded important insights into immunity to HCV, in particular revealing the central role of T cells in viral control and clearance. Other key features of adaptive immune responses remain obscure, including mechanisms by which T cells control HCV replication, the role of antibodies in conferring protection and how cellular and humoral immunity are subverted in persistent infection.
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